Largest Biotech Companies By Market Cap – Biotech funding from the top 10 “youth companies” totaled $3.009 billion this year – a 50% increase from $2.030 billion in 2016.
He explained. But investors don’t need to look to the headlines to see how much biotech stocks have fallen from last year’s highs and market capitalization (stock price yield and outstanding number of shares outstanding).
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It’s best for investors to keep an eye on what’s happening with the many electronic exchange-traded funds (ETFs) that invest in biotech stocks. These ETFs have been sinking since the recession. In fact, low ETFs on A
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“5 Key Reasons Behind Biopharma’s Bear Market”, published Feb. Between the publication of this article and March 7, the largest ETF – the iShares Nasdaq Biotechnology ETF (IBB) – dropped from $131.80 to $120.62. It was an 8.5% drop. (The new price was 30% lower than the IBB record of $172.60 reached on Feb 8, 2021.)
The drop was worse for the SPDR S&P Biotech ETF (XBI), which was down 11% at the end of March 7 from $94.36 to $83.76, losing more than half (52%) of the US high. $173.99 registered on February 8th. 2021.
Despite a bearish biotech market in recent months, the total market capitalization of the 25 biotech companies with the largest market capitalizations, or “market values,” as of March 4 rose to $1.498 trillion year-over-year. But the increase was small (about 4% from $1.445 trillion in March 2021) compared with a 55.5% jump from a total of $963.495 billion.
Among the top 25 biotech companies, market capitalization gainers (14) outnumber losers (11). Interestingly, none of the 77 companies with initial public offerings in 2021 (according to IPOScoop.com) made the top 25 – a possible early sign that investors are reluctant to flock to newly-listed companies.
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An updated list of 25 biotechnology companies, listed by market value as of March 4, 2022, on exchanges where the companies’ shares are traded or other publicly available sources. Each company is listed by rating, name, market value in billions of dollars, and percentage change from the previous year. (
Companies headquartered outside the United States account for more than half (13) of the companies on this year’s list of the top 25 biotechnology companies, compared to less than one.
The 2019 A-list. Of the 13 headquarters outside the United States, three are in China, two in South Korea, two in Denmark, and one in Australia, Belgium, Germany, India, Japan, and Switzerland (but not including a second company with the Switzerland). since he owns the house).
The smallest company listed this year has a market cap of more than $14 billion, compared with just over $10 billion for the 25th ranked company.
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Biomarine Pharmaceuticals, which had a market cap of $13.93 billion as of March 4, is missing from the list of 26, followed by Exact Sciences ($12.37 billion). billion) and Viatris ($11.95 billion), the company formed by the merger of Mylan (No. 25 in There have been more than 500 IPOs and SPACs of biotech startups since 2010. We analyze the big winners and losers of this group, multiplied by IPO valuation • Price change since the IPO.
Seven of the 10 underperformers were platform biotechnology companies. On the other hand, all great performers had perishable properties (approved products or products in critical studies).
SPACs and techbio platforms were the biggest underperformers: 5 of the top 10 losers were SPACs and 5 of the 10 were biotech companies. Yet technology SPACs and IPOs represent a small portion of all biotechnology public market launches. SPACs represent 5% of all new public market entries, but account for 50% of the top 10 worst performing stocks. Similarly, Tech-Bio represents 5% of all entries into the public biopharmaceuticals market and represents 50% of the top 10 worst performing stocks by market cap.
For companies, this poses a paradox: platforms perform poorly, but it takes a platform to build a sustainable enterprise.
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How did you resolve this paradox? One solution is to focus on products first and then build a platform to deliver those products.
We were very product focused and that made a big difference. I know that Cetus was more interested in developing the technology at the time. “Well, let’s make a product and let’s develop the technology we need to make the product, and let the product drive the science, not the other way around,” I said. We actually ended up doing better science because of it, and we got a product.
Three basic laws of biotechnology explain why products are worth more than first-stage platforms and why platform companies are valuable when they develop good products.
In short: the quality of R&D programs is more important than quantity. Most hits that come out of the triage platform have a negative NPV. The lower the quality, the lower the cost of the platform. A valuable platform is one that has access to a small number of useful programs, not a large number of mediocre ones.
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If the above chart holds true, we can expect the best performing stocks to be the laggards.
That’s really what we see in the IPO performance data. The biggest market capitalization winners of the 2010-2021 IPO boom have mature and valuable products.
These companies all have commercial products, products being evaluated for regulatory approval, or products in pivotal studies.
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Many of these companies have platforms in addition to advanced products. But most of its value comes from its assets, not its platform. Arguably, Foundation Medicine was the only company of these companies that was bought for platform value rather than product value.
Even BNTX and MRNA – the two stocks that sparked the platform’s biotech frenzy – are only trading as they develop their Covid vaccines. Before Covid, MRN traded below the IPO price.
Every time you see a biotech stock double or triple on good data, you’re seeing this principle in action. Good clinical data is the currency of value in biotechnology. In particular, good clinical data is data that demonstrates the potential, first-line or in-class, to provide significant clinical benefit to patients with significant unmet need.
To further illustrate the connection between clinical progress and value creation, we can look to CRISPR pioneers Intellia, Editas and CRISPR Therapeutics – the first pre-clinical stage biotechnology IPOs.
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All of these companies have announced pre-clinical valuations of around $550-630 million. Until CRISPR Therapeutics entered the clinic, they traded online. As the CRISPR clinical trial slowly released data showing the drug worked, the market responded by valuing the company.
. Intellia and Editas, who were frozen in the clinic, started trading only when they entered the clinic and later released positive data (the above chart is from our analysis last year; we haven’t updated it for this post, but the overall point still stands ).
Why has CRISPR stock increased in clinical data? Data showed that the CRISPR product provided significant clinical benefit (potential cure) for patients with unmet needs (severe hemoglobinopathies – sickle cell disease and beta thalassemia) and first-line or best-in-class potential (CLINICAL CRISPR program). In severe hemoglobinopathies, Bluebird Bio was side by side with gene therapy research, so it could be first in class, and CRISPR had best in class potential because it uses a non-integrating vector and it uses different techniques — CRISPR — to edit genes).
Information that shows a scientific or technological difference (as opposed to a clinical difference) also does not move stock prices. Scientific and technological diversity matters only insofar as it leads to clinical diversity – a better product for patients. A common investment strategy during the Covid bubble was to identify promising technology trends and then invest in companies with the best technology in the current environment. This strategy misses the important point that products are the means by which new technology realizes its potential.
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Just as investors in the dot-com bubble lost all their money thinking the Internet would change the world, the long-term technological hopes of biotechnology investors may be correct, but they still burn out. Betting solely on technology without considering the fundamentals of the company and the product is a risky strategy, and betting on the fundamentals will not work in the long run.
Above information, public stock investors reward products on platforms. We also saw that most of them made huge profits. How much does a large pharmacy cost?
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They all had defective products – 40% had an approved product, 31% had submitted or were about to submit a regulatory document for approval, and 25% were in pivotal studies.
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